Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease
Identifieur interne : 000B97 ( Main/Exploration ); précédent : 000B96; suivant : 000B98Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease
Auteurs : Damian M. Herz [Allemagne, Danemark] ; Hartwig R. Siebner [Danemark] ; Oliver J. Hulme [Danemark] ; Esther Florin [Allemagne, Canada] ; Mark S. Christensen [Danemark] ; Lars Timmermann [Allemagne]Source :
- NeuroImage : (Orlando, Fla.) [ 1053-8119 ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Dopamine deficiency affects functional integration of activity in distributed neural regions. It has been suggested that lack of dopamine induces disruption of neural interactions between prefrontal and premotor areas, which might underlie impairment of motor control observed in patients with Parkinson's disease (PD). In this study we recorded cortical activity with high-density electroencephalography in 11 patients with PD as a pathological model of dopamine deficiency, and 13 healthy control subjects. Participants performed repetitive extension-flexion movements of their right index finger, which were externally paced at a rate of 0.5 Hz. This required participants to align their movement velocity to the slow external pace. Patients were studied after at least 12-hour withdrawal of dopaminergic medication (OFF state) and after intake of the dopamine precursor levodopa (ON state) in order to examine oscillatory coupling between prefrontal and premotor areas during respectively low and high levels of dopamine. In 10 patients and 12 control participants multiple source beamformer analysis yielded task-related activation of a contralateral cortical network comprising prefrontal cortex (PFC), lateral premotor cortex (IPM), supplementary motor area (SMA) and primary motor cortex (M1). Dynamic causal modelling was used to characterize task-related oscillatory coupling between prefrontal and premotor cortical areas. Healthy participants showed task-induced coupling from PFC to SMA, which was modulated within the γ-band. In the OFF state, PD patients did not express any frequency-specific coupling between prefrontal and premotor areas. Application of levodopa reinstated task-related coupling from PFC to SMA, which was expressed as high-β-γ coupling. Additionally, strong within-frequency γ-coupling as well as cross-frequency θ-γ coupling was observed from PFC to 1PM. Enhancement of this cross-frequency θ-γ coupling after application of levodopa was positively correlated with individual improvement in motor function. The results demonstrate that dopamine deficiency impairs the ability to establish oscillatory coupling between prefrontal and premotor areas during an externally paced motor task. Application of extrinsic dopamine in PD patients reinstates physiological prefrontal-premotor coupling and additionally induces within- and cross-frequency coupling from prefrontal to premotor areas, which is not expressed in healthy participants.
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Siebner</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre</s1><s2>Hvidovre</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Hvidovre</wicri:noRegion></affiliation></author><author><name sortKey="Hulme, Oliver J" sort="Hulme, Oliver J" uniqKey="Hulme O" first="Oliver J." last="Hulme">Oliver J. Hulme</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre</s1><s2>Hvidovre</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Hvidovre</wicri:noRegion></affiliation></author><author><name sortKey="Florin, Esther" sort="Florin, Esther" uniqKey="Florin E" first="Esther" last="Florin">Esther Florin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s2>Cologne</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Christensen, Mark S" sort="Christensen, Mark S" uniqKey="Christensen M" first="Mark S." last="Christensen">Mark S. Christensen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre</s1><s2>Hvidovre</s2><s3>DNK</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Hvidovre</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Nutrition, Exercise and Sports, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neuroscience and Pharmacology, University of Copenhagen</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>5 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Cologne</s1><s2>Cologne</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University Hospital Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">NeuroImage : (Orlando, Fla.)</title><title level="j" type="abbreviated">NeuroImage : (Orlando Fla.)</title><idno type="ISSN">1053-8119</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">NeuroImage : (Orlando, Fla.)</title><title level="j" type="abbreviated">NeuroImage : (Orlando Fla.)</title><idno type="ISSN">1053-8119</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Electroencephalography</term><term>Levodopa</term><term>Parkinson disease</term><term>Prefrontal cortex</term><term>Premotor cortex</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lévodopa</term><term>Cortex préfrontal</term><term>Cortex prémoteur</term><term>Electroencéphalographie</term><term>Maladie de Parkinson</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine deficiency affects functional integration of activity in distributed neural regions. It has been suggested that lack of dopamine induces disruption of neural interactions between prefrontal and premotor areas, which might underlie impairment of motor control observed in patients with Parkinson's disease (PD). In this study we recorded cortical activity with high-density electroencephalography in 11 patients with PD as a pathological model of dopamine deficiency, and 13 healthy control subjects. Participants performed repetitive extension-flexion movements of their right index finger, which were externally paced at a rate of 0.5 Hz. This required participants to align their movement velocity to the slow external pace. Patients were studied after at least 12-hour withdrawal of dopaminergic medication (OFF state) and after intake of the dopamine precursor levodopa (ON state) in order to examine oscillatory coupling between prefrontal and premotor areas during respectively low and high levels of dopamine. In 10 patients and 12 control participants multiple source beamformer analysis yielded task-related activation of a contralateral cortical network comprising prefrontal cortex (PFC), lateral premotor cortex (IPM), supplementary motor area (SMA) and primary motor cortex (M1). Dynamic causal modelling was used to characterize task-related oscillatory coupling between prefrontal and premotor cortical areas. Healthy participants showed task-induced coupling from PFC to SMA, which was modulated within the γ-band. In the OFF state, PD patients did not express any frequency-specific coupling between prefrontal and premotor areas. Application of levodopa reinstated task-related coupling from PFC to SMA, which was expressed as high-β-γ coupling. Additionally, strong within-frequency γ-coupling as well as cross-frequency θ-γ coupling was observed from PFC to 1PM. Enhancement of this cross-frequency θ-γ coupling after application of levodopa was positively correlated with individual improvement in motor function. The results demonstrate that dopamine deficiency impairs the ability to establish oscillatory coupling between prefrontal and premotor areas during an externally paced motor task. Application of extrinsic dopamine in PD patients reinstates physiological prefrontal-premotor coupling and additionally induces within- and cross-frequency coupling from prefrontal to premotor areas, which is not expressed in healthy participants.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Danemark</li></country><region><li>Hovedstaden</li><li>Québec</li></region><settlement><li>Copenhague</li><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Herz, Damian M" sort="Herz, Damian M" uniqKey="Herz D" first="Damian M." last="Herz">Damian M. Herz</name></noRegion><name sortKey="Florin, Esther" sort="Florin, Esther" uniqKey="Florin E" first="Esther" last="Florin">Esther Florin</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></country><country name="Danemark"><noRegion><name sortKey="Herz, Damian M" sort="Herz, Damian M" uniqKey="Herz D" first="Damian M." last="Herz">Damian M. Herz</name></noRegion><name sortKey="Christensen, Mark S" sort="Christensen, Mark S" uniqKey="Christensen M" first="Mark S." last="Christensen">Mark S. Christensen</name><name sortKey="Christensen, Mark S" sort="Christensen, Mark S" uniqKey="Christensen M" first="Mark S." last="Christensen">Mark S. Christensen</name><name sortKey="Christensen, Mark S" sort="Christensen, Mark S" uniqKey="Christensen M" first="Mark S." last="Christensen">Mark S. Christensen</name><name sortKey="Hulme, Oliver J" sort="Hulme, Oliver J" uniqKey="Hulme O" first="Oliver J." last="Hulme">Oliver J. Hulme</name><name sortKey="Siebner, Hartwig R" sort="Siebner, Hartwig R" uniqKey="Siebner H" first="Hartwig R." last="Siebner">Hartwig R. Siebner</name></country><country name="Canada"><region name="Québec"><name sortKey="Florin, Esther" sort="Florin, Esther" uniqKey="Florin E" first="Esther" last="Florin">Esther Florin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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